MDA REG. NO. :GD790221148718
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EXPIRY DATE : 01/2027
ABSTRACT
Application of pharmaceutical nanotechnology (nanomedicines) FROM PLANT actives and extracts, is gaining a tremendous growth and interest among the scientists. This emerging herbal revolution has headed towards the development of another approaches for the delivery of poorly soluble herbal bioactives and plant extracts for enhancing their bioavailability and efficacy. In the same context, a majority of pharmaceutical nanotechnologies and targeting strategies including phytosomes, nanoparticles, hydrogels, microspheres, transferosomes and ethosomes, self nano emulsifying drug delivery systems (SNEDDS), self micro emulsifying drug delivery systems (SMEDDS) has been applied for the delivery of bioactives and plant extracts and were identified and explored. These pharmaceutical nanotechnologies have been proven to be the most efficient and reliable delivery systems, as these enhance the solubility, absorption, pharmacokinetics, bioavailability and provide protection from toxicity. Considering these aspects, the present review highlights the present scenario related to the expansion of novel herbal formulations utilizing the nanotechnologies and compilation of their delivery types and mechanism, methodology, loaded drug, drug size, entrapment efficiency of drug, in vivo activity and its application. Moreover, this review article provides an understanding of therapeutic efficacy of the herbal medicines to be loaded into the novel drug delivery system for various biomedical applications.
SURGISPON® Absorbable Hemostatic Gelatin Sponge is a quick and effective hemostatic which stops bleeding fast. It reduces intra operative bleeding and surgery time. SURGISPON® is non-toxic, non-allergenic, non-immunogenic, and non- pyrogenic. SURGISPON® is already gamma-sterilized, and thus does not need to be resterilized. It is available in a convenient, ready to tear sterile blister/envelope, SURGISPON® unlike many haemostatic agents, does not require special storage conditions. The uniform porosity of SURGISPON® guarantees a favourable haemostasis. When implanted in vivo, it is completely absorbed within 3-4 weeks, with no residue and no encapsulation.
HOW IT WORKS
SURGISPON® adheres to the bleeding site and absorbs approximately 45 times of its own weight of blood. It has a porous structure which activates the thrombocytes at the moment blood comes in contact with the matrix of the sponge. This causes the thrombocytes to release a series of substances which promote their aggregation at the same time as their surfaces change character, thus enabling them to act as a catalyst for the formation of the fibrin, which stops the bleeding. When implanted in the tissues, it is absorbed within 3-4 weeks.
KEY BENEFITS
SURGISPON® fulfils the surgical need for haemostasis with simple efficiency:
- Saves Valuable time for surgeons
- Reduces post operative time and fastens recovery time for the patient
- Gamma Sterile and ready to use
- Easy to cut according to need
- Secure and speedy haemostasis
- Significantly reduces blood loss
- Absorbs 40-50 times its own weight of water/oxalate blood
- No reported side effects
- Does not interfere with tissue healing
- Leaves no residue and encapsulation
- Extremely Cost effective